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Introduction to Percocet

Percocet is a combination medication containing Oxycodone and Acetaminophen used to treat moderate to severe pain. It is often buyd online with a prescription when not available over the counter. Other pain medications may not provide enough relief, making Percocet a preferred option.


Oxycodone is an opioid analgesic drug, while Acetaminophen is a nonopioid pain reliever. The combination is effective in treating pain and reducing fever. The exact mechanism of action is not fully understood, but specific CNS opioid receptors have been identified that play a crucial role in the analgesic effects of Percocet.

Metabolism and Elimination From the System

Percocet is metabolized in the liver to Noroxycodone, while Acetaminophen is rapidly absorbed from the gastrointestinal tract to the liver. The medication has an average elimination half-life of 3-4 hours, and it takes 20-24 hours to eliminate all of it from the system via the excretory system.

Accurate Usage and Dosage Procedure

It is crucial to follow the rules of the Opioid Analgesic REMS therapy to prevent addiction, abuse, and misuse of Oxycodone and Acetaminophen combination medications. Percocet should be taken as prescribed, and extended-release tablets should be swallowed whole with water. Do not crush, break, chew, dissolve, snort, or inject the contents. Consult with your doctor before changing dosage formulations or exceeding 4 grams of Acetaminophen in a single day.

Available Variants

Percocet is available in various forms, including capsules, tablets, and oral solutions. The recommended dosage for severe pain in adults is 1 capsule every 6 hours or 1-2 tablets depending on strength. The maximal daily dose should not exceed 12 tablets. The oral solution is generally recommended every 6 hours, not exceeding 60 mL or 12 teaspoons in a single day.

Overdose Symptoms of Percocet

Percocet is a Schedule II controlled substance drug that can cause an overdose if taken in excess. Symptoms include vomiting, slurred speech, slowed heart rate, nausea, memory loss, loss of consciousness, labored breathing, coma, abdominal cramps, and more.

Side Effects

Common side effects of Percocet include shallow breathing, lightheadedness, weakness, tiredness, confusion, behavioral changes, problems with urination, nausea, stomach pain and loss of appetite, dark-colored urine and stool, vomiting, dizziness, drowsiness, constipation, severe headaches, and more.

Interactions of Percocet With Other Drugs

Percocet can interact with a wide range of medications and substances, including alcohol, marijuana, ethanol, grapefruit juice, tobacco, other opioid painkillers, sedatives, sleeping medications, depression and anxiety medicines, medicine for Parkinson’s disease, and more. It is crucial to consult with your healthcare provider about any potential interactions before taking Percocet.

Percocet Misuse and Abuse

Percocet is often abused for its narcotic and euphoric effects. Abusing the medication regularly can lead to addiction and long-term damage to an individual’s system. Behavioral changes observed in addicts include stealing Percocet tablets or money to buy them, taking greater doses than prescribed, social isolation or withdrawal, attempting to obtain an illegal prescription, and more.


Individuals who have been taking Percocet regularly may become physically dependent on the medication. Gradual downward titration of the dose is necessary to prevent withdrawal symptoms such as tremors, nausea and vomiting, diarrhea, hypertension, increased heart rate, muscle spasms, runny nose, restlessness, irritability, anxiety, and depression. Abrupt discontinuation of Percocet should be avoided.


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