Suboxone 8 mg is a medication that contains buprenorphine hydrochloride and naloxone hydrochloride dihydrate. Buprenorphine is a partial agonist that affects the mu-opioid receptor and an antagonist acting at the kappa-opioid receptor, while naloxone is an antagonist working at the mu-opioid receptor. Suboxone is available in two dosage strengths, Suboxone 2 mg and Suboxone 8 mg.
Working in The System
Buprenorphine exerts agonistic effects at mu and delta opioid receptors in CNS, while naloxone produces opioid withdrawal signs and symptoms in individuals who are physically dependent on full opioid agonists. After metabolization and absorption from the gastrointestinal tract, residual Suboxone is eliminated from an individual’s system via urine and feces.
How to Use Suboxone Pills
Suboxone tablets should be placed under the tongue and allowed to dissolve gradually. An individual may start the treatment with an initial dose of Suboxone 2 mg /0.5 mg. The daily dose should not exceed 24 mg of buprenorphine. Once the individual’s system is observed to be stabilized, the maintenance dose of Suboxone may be reduced gradually, and eventually, the treatment can be stopped.
Missed Dose and Overdosing on Suboxone
Take the missed dose of Suboxone 8 mg medicine as soon as you can, but you may skip the missed dose if it is almost time for the next dose. Never take multiple doses at a time. An opioid drug overdose situation may arrive when an individual takes an inappropriate dose of Suboxone in a day. This can be fatal, especially in children or any individual using the medicine without a prescription.
Do Not Co-Administer Suboxone 8 mg with:
Sedatives such as benzodiazepines or related products should be prohibited along with Suboxone. The simultaneous use of opioids with sedative medicinal products may increase the risk of sedation, respiratory depression, coma, and even death. Serotonergic medicinal products, alcohol, marijuana, and other narcotic products can promote severe sedation and drowsiness when taken along with Suboxone 8 mg tablets.
Suboxone 8 mg During Pregnancy
Long-term administration of this drug during the last three months of pregnancy may cause withdrawal syndrome in the neonate. Furthermore, an individual may use Suboxone 8 mg during pregnancy only after assessing its potential benefits. It is unknown whether the Naloxone drug is excreted in human milk or not, but studies show that Buprenorphine and its metabolites are excreted in human milk. Therefore, breastfeeding should be discontinued during treatment with Suboxone 8 mg pills or vice versa.