Interactions between Percocet and Tylenol with Codeine #3

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Interactions between your drugs

This report displays the potential drug interactions for the following 2 drugs:

– Percocet (acetaminophen/oxycodone)

– Tylenol with Codeine #3 (acetaminophen/codeine)

Please consult with your doctor if you have any questions or concerns regarding these medications. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including respiratory distress, coma, and even death. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Please note that alcohol or medications that contain alcohol should not be used while receiving treatment with oxyCODONE. This may increase nervous system side effects such as drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. In severe cases, low blood pressure, respiratory distress, fainting, coma, or even death may occur. You may also want to avoid or limit the consumption of grapefruit and grapefruit juice, which can significantly increase the blood levels of oxycodone in some people. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of oxyCODONE, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can have potentially adverse consequences. The recommended maximum number of medicines in the ‘acetaminophen’ category to be taken concurrently is usually one. Your list includes two medicines belonging to the ‘acetaminophen’ category: Percocet (acetaminophen/oxycodone) and Tylenol with Codeine #3 (acetaminophen/codeine). Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

– Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

– Moderate: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

– Minor: Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

– Unknown: No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer