Can Fatty Liver Disease be Inherited?

Understanding Fatty Liver Disease

Fatty liver disease is a condition that occurs when there is a buildup of fat in the liver cells. While alcohol abuse is a common cause, nonalcoholic fatty liver disease (NAFLD) can also develop without alcohol consumption. This disease can be difficult to detect as it may not present with any symptoms or only a few. However, scientists suspect that metabolic syndrome and insulin resistance may contribute to its development.

Participating in Clinical Trials for Liver Disease

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Fatty Liver Disease and Heritability

NAFLD is a complex disorder with both environmental and genetic contributions. Twin studies have shown that heritability is around 50% for liver fat accumulation and scarring (fibrosis). While having family members with fatty liver disease does not guarantee that you will develop the disease, you may be more susceptible.

Common Causes and Risk Factors of Fatty Liver Disease

Researchers have not identified one specific cause of fatty liver disease, but certain factors can increase the likelihood of its development. These include eating too many calories, obesity, diabetes, dyslipidemia, metabolic syndrome, and insulin resistance. Fatty liver disease is the most common liver disease, affecting around 24% of US adults. Gender and ethnicity may also affect your likelihood of developing the disease.

Protecting Your Liver

There are multiple ways to avoid damaging your liver, including minimizing alcohol consumption, washing produce to minimize toxins from pesticides, exercising, eating a healthy balanced diet, getting vaccinated for hepatitis A, B, and C, practicing safe sex, and washing your hands regularly.

Treating Fatty Liver Disease

While there are currently no medications to reverse or cure fatty liver disease, lifestyle changes can help. Losing at least 5-7% of your total body weight can reduce symptoms, but it requires a slow, controlled process with the help of your healthcare provider. If fatty liver disease progresses, it can lead to cirrhosis of the liver, which is scarring and damage that is much harder to manage. It’s essential to identify the disease close to its onset and protect your liver as much as possible.